An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity

The HIV-1 envelope glycoprotein (Env) (gp120-gp41)(3) is the target for neutralizing antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible, sampling different conformational states. Before engaging CD4, Env adopts a closed conformation (State 1) that is largely antibo...

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Publicado no:Cell Host Microbe
Main Authors: Alsahafi, Nirmin, Bakouche, Nordine, Kazemi, Mohsen, Richard, Jonathan, Ding, Shilei, Bhattacharyya, Sudipta, Das, Durba, Anand, Sai Priya, Prévost, Jérémie, Tolbert, William D., Lu, Hong, Medjahed, Halima, Gendron-Lepage, Gabrielle, Delgado, Gloria Gabrielle Ortega, Kirk, Sharon, Melillo, Bruno, Mothes, Walther, Sodroski, Joseph, Smith, Amos B., Kaufmann, Daniel E., Wu, Xueling, Pazgier, Marzena, Rouiller, Isabelle, Finzi, Andrés, Munro, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592637/
https://ncbi.nlm.nih.gov/pubmed/30974085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.03.002
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