A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity

The HIV-1 envelope glycoprotein (Env) trimer mediates virus entry into cells. The “closed” conformation of Env is resistant to nonneutralizing antibodies (nnAbs). These antibodies mostly recognize occluded epitopes that can be exposed upon binding of CD4 or small-molecule CD4 mimetics (CD4mc). Here,...

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Veröffentlicht in:J Virol
Hauptverfasser: Ding, Shilei, Grenier, Melissa C., Tolbert, William D., Vézina, Dani, Sherburn, Rebekah, Richard, Jonathan, Prévost, Jérémie, Chapleau, Jean-Philippe, Gendron-Lepage, Gabrielle, Medjahed, Halima, Abrams, Cameron, Sodroski, Joseph, Pazgier, Marzena, Smith, Amos B., Finzi, Andrés
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880173/
https://ncbi.nlm.nih.gov/pubmed/31554684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01325-19
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