A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity

The HIV-1 envelope glycoprotein (Env) trimer mediates virus entry into cells. The “closed” conformation of Env is resistant to nonneutralizing antibodies (nnAbs). These antibodies mostly recognize occluded epitopes that can be exposed upon binding of CD4 or small-molecule CD4 mimetics (CD4mc). Here,...

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Vydáno v:J Virol
Hlavní autoři: Ding, Shilei, Grenier, Melissa C., Tolbert, William D., Vézina, Dani, Sherburn, Rebekah, Richard, Jonathan, Prévost, Jérémie, Chapleau, Jean-Philippe, Gendron-Lepage, Gabrielle, Medjahed, Halima, Abrams, Cameron, Sodroski, Joseph, Pazgier, Marzena, Smith, Amos B., Finzi, Andrés
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880173/
https://ncbi.nlm.nih.gov/pubmed/31554684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01325-19
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