A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity

The HIV-1 envelope glycoprotein (Env) trimer mediates virus entry into cells. The “closed” conformation of Env is resistant to nonneutralizing antibodies (nnAbs). These antibodies mostly recognize occluded epitopes that can be exposed upon binding of CD4 or small-molecule CD4 mimetics (CD4mc). Here,...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Ding, Shilei, Grenier, Melissa C., Tolbert, William D., Vézina, Dani, Sherburn, Rebekah, Richard, Jonathan, Prévost, Jérémie, Chapleau, Jean-Philippe, Gendron-Lepage, Gabrielle, Medjahed, Halima, Abrams, Cameron, Sodroski, Joseph, Pazgier, Marzena, Smith, Amos B., Finzi, Andrés
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880173/
https://ncbi.nlm.nih.gov/pubmed/31554684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01325-19
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