A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity

The HIV-1 envelope glycoprotein (Env) trimer mediates virus entry into cells. The “closed” conformation of Env is resistant to nonneutralizing antibodies (nnAbs). These antibodies mostly recognize occluded epitopes that can be exposed upon binding of CD4 or small-molecule CD4 mimetics (CD4mc). Here,...

詳細記述

保存先:
書誌詳細
出版年:J Virol
主要な著者: Ding, Shilei, Grenier, Melissa C., Tolbert, William D., Vézina, Dani, Sherburn, Rebekah, Richard, Jonathan, Prévost, Jérémie, Chapleau, Jean-Philippe, Gendron-Lepage, Gabrielle, Medjahed, Halima, Abrams, Cameron, Sodroski, Joseph, Pazgier, Marzena, Smith, Amos B., Finzi, Andrés
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2019
主題:
Pathogenesis and Immunity
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880173/
https://ncbi.nlm.nih.gov/pubmed/31554684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01325-19
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