The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain topological layers facilitate the transition of Env to the CD4-bound conformation. CD4 engages gp120 by introducing its phenylalanin...

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書誌詳細
出版年:mBio
主要な著者: Prévost, Jérémie, Tolbert, William D., Medjahed, Halima, Sherburn, Rebekah T., Madani, Navid, Zoubchenok, Daria, Gendron-Lepage, Gabrielle, Gaffney, Althea E., Grenier, Melissa C., Kirk, Sharon, Vergara, Natasha, Han, Changze, Mann, Brendan T., Chénine, Agnès L., Ahmed, Adel, Chaiken, Irwin, Kirchhoff, Frank, Hahn, Beatrice H., Haim, Hillel, Abrams, Cameron F., Smith, Amos B., Sodroski, Joseph, Pazgier, Marzena, Finzi, Andrés
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251204/
https://ncbi.nlm.nih.gov/pubmed/32457241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00280-20
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