Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses

HIV-1-infected cells expressing envelope glycoproteins (Env) in the CD4-bound conformation on their surfaces are targeted by antibody-dependent cellular cytotoxicity (ADCC) mediated by CD4-induced (CD4i) antibodies and sera from HIV-1-infected individuals (HIV(+) sera). By downregulating the surface...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Prévost, Jérémie, Richard, Jonathan, Medjahed, Halima, Alexander, Audrey, Jones, Jennifer, Kappes, John C., Ochsenbauer, Christina, Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002730/
https://ncbi.nlm.nih.gov/pubmed/29669829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00484-18
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