Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

HIV-1 Nef clones isolated from a rare subset of HIV-1-infected elite controllers (EC), with the ability to suppress viral load to undetectable levels in the absence of antiretroviral therapy, are unable to fully downregulate CD4 from the plasma membrane of CD4(+) T cells. Residual CD4 left at the pl...

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Udgivet i:J Virol
Main Authors: Alsahafi, Nirmin, Richard, Jonathan, Prévost, Jérémie, Coutu, Mathieu, Brassard, Nathalie, Parsons, Matthew S., Kaufmann, Daniel E., Brockman, Mark, Finzi, Andrés
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533916/
https://ncbi.nlm.nih.gov/pubmed/28615199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00109-17
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