Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses

HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound conformation on their surface are preferentially targeted by antibody-dependent cellular-mediated cytotoxicity (ADCC). HIV-1 has evolved sophisticated mechanisms to avoid the exposure of Env ADCC epitopes by downregulating...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Prévost, Jérémie, Zoubchenok, Daria, Richard, Jonathan, Veillette, Maxime, Pacheco, Beatriz, Coutu, Mathieu, Brassard, Nathalie, Parsons, Matthew S., Ruxrungtham, Kiat, Bunupuradah, Torsak, Tovanabutra, Sodsai, Hwang, Kwan-Ki, Moody, M. Anthony, Haynes, Barton F., Bonsignori, Mattia, Sodroski, Joseph, Kaufmann, Daniel E., Shaw, George M., Chenine, Agnès L., Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355605/
https://ncbi.nlm.nih.gov/pubmed/28100618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02452-16
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