Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env

To minimize immune responses against infected cells, HIV-1 limits the surface expression of its envelope glycoprotein (Env). Here, we demonstrate that this mechanism is specific for the Env conformation and affects the efficiency of antibody-dependent cellular cytotoxicity (ADCC). Using flow cytomet...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Anand, Sai Priya, Grover, Jonathan R., Tolbert, William D., Prévost, Jérémie, Richard, Jonathan, Ding, Shilei, Baril, Sophie, Medjahed, Halima, Evans, David T., Pazgier, Marzena, Mothes, Walther, Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532100/
https://ncbi.nlm.nih.gov/pubmed/30894474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00293-19
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