Grafting Neural Stem and Progenitor Cells Into the Hippocampus of Juvenile, Irradiated Mice Normalizes Behavior Deficits

The pool of neural stem and progenitor cells (NSPCs) in the dentate gyrus of the hippocampus is reduced by ionizing radiation. This explains, at least partly, the learning deficits observed in patients after radiotherapy, particularly in pediatric cases. An 8 Gy single irradiation dose was delivered...

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Publicat a:Front Neurol
Autors principals: Sato, Yoshiaki, Shinjyo, Noriko, Sato, Machiko, Nilsson, Marie K. L., Osato, Kazuhiro, Zhu, Changlian, Pekna, Marcela, Kuhn, Hans G., Blomgren, Klas
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Neurology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141740/
https://ncbi.nlm.nih.gov/pubmed/30254600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00715
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