Grafting of neural stem and progenitor cells to the hippocampus of young, irradiated mice causes gliosis and disrupts the granule cell layer

Ionizing radiation persistently reduces the pool of neural stem and progenitor cells (NSPCs) in the dentate gyrus (DG) of the hippocampus, which may explain some of the learning deficits observed in patients treated with radiotherapy, particularly pediatric patients. A single dose of 8 Gy irradiatio...

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Main Authors: Sato, Y, Shinjyo, N, Sato, M, Osato, K, Zhu, C, Pekna, M, Kuhn, H G, Blomgren, K
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668629/
https://ncbi.nlm.nih.gov/pubmed/23598403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.92
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