Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2

MeCP2 is a nuclear protein that is mutated in the severe neurological disorder Rett syndrome (RTT). The ability to target β-galactosidase to the nucleus was previously used to identify a conserved nuclear localization signal (NLS) in MeCP2 that interacts with the nuclear import factors KPNA3 and KPN...

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Vydáno v:Cell Rep
Hlavní autoři: Lyst, Matthew J., Ekiert, Robert, Guy, Jacky, Selfridge, Jim, Koerner, Martha V., Merusi, Cara, De Sousa, Dina, Bird, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130050/
https://ncbi.nlm.nih.gov/pubmed/30157418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.099
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