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Sequence‐specific DNA binding by AT‐hook motifs in MeCP2

MeCP2 is a chromatin‐associated protein that is mutated in Rett syndrome. Its methyl‐CpG‐binding domain interacts with DNA containing methylated cytosine, but other modes of recruitment to the genome have also been proposed. Here, we use in vitro and in vivo assays to investigate the DNA binding spe...

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Udgivet i:FEBS Lett
Main Authors: Lyst, Matthew J., Connelly, John, Merusi, Cara, Bird, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028900/
https://ncbi.nlm.nih.gov/pubmed/27461740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12328
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