An antibacterial β-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis

The spread of antibiotic resistance is a major challenge for treatment of Mycobacterium tuberculosis infection. In addition, efficacy of drugs is often limited by the restricted permeability of the mycomembrane. Frontline antibiotics inhibit mycomembrane biosynthesis leading to rapid cell death. Ins...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Lehmann, Johannes, Cheng, Tan-Yun, Aggarwal, Anup, Park, Annie S., Zeiler, Evelyn, Raju, Ravikiran M., Akopian, Tatos, Kandror, Olga, Bach, Nina C., Sacchettini, James C., Branch Moody, D., Rubin, Eric J., Sieber, Stephan A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104829/
https://ncbi.nlm.nih.gov/pubmed/29067779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201709365
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