An antibacterial β-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis

The spread of antibiotic resistance is a major challenge for treatment of Mycobacterium tuberculosis infection. In addition, efficacy of drugs is often limited by the restricted permeability of the mycomembrane. Frontline antibiotics inhibit mycomembrane biosynthesis leading to rapid cell death. Ins...

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Bibliografiset tiedot
Julkaisussa:Angew Chem Int Ed Engl
Päätekijät: Lehmann, Johannes, Cheng, Tan-Yun, Aggarwal, Anup, Park, Annie S., Zeiler, Evelyn, Raju, Ravikiran M., Akopian, Tatos, Kandror, Olga, Bach, Nina C., Sacchettini, James C., Branch Moody, D., Rubin, Eric J., Sieber, Stephan A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104829/
https://ncbi.nlm.nih.gov/pubmed/29067779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201709365
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