Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis

In Mycobacterium tuberculosis, mycolic acids and their glycerol, glucose, and trehalose esters (“cord factor”) form the main part of the mycomembrane. Despite their first isolation almost a century ago, full stereochemical evaluation is lacking, as is a scalable synthesis required for accurate immun...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Tahiri, Nabil, Fodran, Peter, Jayaraman, Dhineshkumar, Buter, Jeffrey, Witte, Martin D., Ocampo, Tonatiuh A., Moody, D. Branch, Van Rhijn, Ildiko, Minnaard, Adriaan J.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216993/
https://ncbi.nlm.nih.gov/pubmed/32067294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202000523
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