Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

Infection with the bacterial pathogen Mycobacterium tuberculosis imposes an enormous burden on global public health. New antibiotics are urgently needed to combat the global tuberculosis pandemic; however, the development of new small molecules is hindered by a lack of validated drug targets. Here,...

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Detalles Bibliográficos
Main Authors: Stanley, Sarah A., Kawate, Tomohiko, Iwase, Noriaki, Shimizu, Motohisa, Clatworthy, Anne E., Kazyanskaya, Edward, Sacchettini, James C., Ioerger, Thomas R., Siddiqi, Noman A., Minami, Shoko, Aquadro, John A., Schmidt Grant, Sarah, Rubin, Eric J., Hung, Deborah T.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710825/
https://ncbi.nlm.nih.gov/pubmed/23798446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302114110
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