Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

Infection with the bacterial pathogen Mycobacterium tuberculosis imposes an enormous burden on global public health. New antibiotics are urgently needed to combat the global tuberculosis pandemic; however, the development of new small molecules is hindered by a lack of validated drug targets. Here,...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Stanley, Sarah A., Kawate, Tomohiko, Iwase, Noriaki, Shimizu, Motohisa, Clatworthy, Anne E., Kazyanskaya, Edward, Sacchettini, James C., Ioerger, Thomas R., Siddiqi, Noman A., Minami, Shoko, Aquadro, John A., Schmidt Grant, Sarah, Rubin, Eric J., Hung, Deborah T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710825/
https://ncbi.nlm.nih.gov/pubmed/23798446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302114110
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk