Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the genetic hallmark of this disease. In this study, a broad range...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Tsafou, Kalliopi, Katschnig, Anna Maria, Radic-Sarikas, Branka, Mutz, Cornelia Noëlle, Iljin, Kristiina, Schwentner, Raphaela, Kauer, Maximilian O., Mühlbacher, Karin, Aryee, Dave N.T., Westergaard, David, Haapa-Paananen, Saija, Fey, Vidal, Superti-Furga, Giulio, Toretsky, Jeffrey, Brunak, Søren, Kovar, Heinrich
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2018
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089552/
https://ncbi.nlm.nih.gov/pubmed/30123424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25760
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