EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway

Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS‐FLI1. We report that EWS‐FLI1 suppresses TDO2‐mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS‐FLI1‐dependent regulation of TRP metabolism. TRP consumption incre...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Mutz, Cornelia N., Schwentner, Raphaela, Kauer, Maximilian O., Katschnig, Anna M., Kromp, Florian, Aryee, Dave N. T., Erhardt, Sophie, Goiny, Michel, Alonso, Javier, Fuchs, Dietmar, Kovar, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Letters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988508/
https://ncbi.nlm.nih.gov/pubmed/27282934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12243
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