EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing’s Sarcoma

Although p53 is the most frequently mutated gene in cancer, half of human tumors retain wild-type p53, whereby it is unknown whether normal p53 function is compromised by other cancer-associated alterations. One example is Ewing’s sarcoma family tumors (ESFT), where 90% express wild-type p53. ESFT a...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ban, Jozef, Bennani-Baiti, Idriss M., Kauer, Max, Schaefer, Karl-Ludwig, Poremba, Christopher, Jug, Gunhild, Schwentner, Raphaela, Smrzka, Oskar, Muehlbacher, Karin, Aryee, Dave N.T., Kovar, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964910/
https://ncbi.nlm.nih.gov/pubmed/18757425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6145
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