EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma

Ewing sarcoma (EWS) is a paediatric bone cancer with high metastatic potential. Cellular plasticity resulting from dynamic cytoskeletal reorganization, typically regulated via the Rho pathway, is a prerequisite for metastasis initiation. Here, we interrogated the role of the Ewing sarcoma driver onc...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Katschnig, A M, Kauer, M O, Schwentner, R, Tomazou, E M, Mutz, C N, Linder, M, Sibilia, M, Alonso, J, Aryee, D N T, Kovar, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666320/
https://ncbi.nlm.nih.gov/pubmed/28671673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.202
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