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O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing’s sarcoma
The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing’s sarcoma family tumors (ESFT). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition of EWS-FLI1 activity holds high therapeutic promise. Since the activity of many transcript...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4959569/ https://ncbi.nlm.nih.gov/pubmed/19151750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.484 |
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