Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma

The Ewing sarcoma (ES) EWS-FLI1 chimeric oncoprotein is a prototypic aberrant ETS transcription factor with activating and repressive regulatory functions. We report that EWS-FLI1-repressed promoters are enriched in forkhead box (FOX) recognition motifs, and identify FOXO1 as a EWS-FLI1-suppressed r...

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Detalhes bibliográficos
Main Authors: Niedan, S, Kauer, M, Aryee, D N T, Kofler, R, Schwentner, R, Meier, A, Pötschger, U, Kontny, U, Kovar, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114138/
https://ncbi.nlm.nih.gov/pubmed/23995784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.361
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