Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures

Facioscapulohumeral muscular dystrophy (FSHD) is caused by insufficient epigenetic repression of D4Z4 macrosatellite repeat where DUX4, an FSHD causing gene is embedded. There are two forms of FSHD, FSHD1 with contraction of D4Z4 repeat and FSHD2 with chromatin compaction defects mostly due to SMCHD...

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Publié dans:Hum Mol Genet
Auteurs principaux: Lim, Jong-Won, Wong, Chao-Jen, Yao, Zizhen, Tawil, Rabi, van der Maarel, Silvère M, Miller, Daniel G, Tapscott, Stephen J, Filippova, Galina N
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048983/
https://ncbi.nlm.nih.gov/pubmed/29741619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy173
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