Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells

Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of the double-homeodomain transcription factor DUX4 in skeletal muscle cells. Many different cell culture models have been developed to study the pathophysiology of FSHD, frequently based on endogenous expression of DUX4 in FSHD ce...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Jagannathan, Sujatha, Shadle, Sean C., Resnick, Rebecca, Snider, Lauren, Tawil, Rabi N., van der Maarel, Silvère M., Bradley, Robert K., Tapscott, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078597/
https://ncbi.nlm.nih.gov/pubmed/28171552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw271
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