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DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

Facioscapulohumeral dystrophy (FSHD) is caused by decreased epigenetic repression of the D4Z4 macrosatellite array and recent studies have shown that this results in the expression of low levels of the DUX4 mRNA in skeletal muscle. Several other mechanisms have been suggested for FSHD pathophysiolog...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yao, Zizhen, Snider, Lauren, Balog, Judit, Lemmers, Richard J.L.F., Van Der Maarel, Silvère M., Tawil, Rabi, Tapscott, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168822/
https://ncbi.nlm.nih.gov/pubmed/24861551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu251
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