DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

Facioscapulohumeral dystrophy (FSHD) is caused by decreased epigenetic repression of the D4Z4 macrosatellite array and recent studies have shown that this results in the expression of low levels of the DUX4 mRNA in skeletal muscle. Several other mechanisms have been suggested for FSHD pathophysiolog...

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Bibliographic Details
Main Authors: Yao, Zizhen, Snider, Lauren, Balog, Judit, Lemmers, Richard J.L.F., Van Der Maarel, Silvère M., Tawil, Rabi, Tapscott, Stephen J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168822/
https://ncbi.nlm.nih.gov/pubmed/24861551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu251
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