DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis

The human double-homeodomain retrogene DUX4 is expressed in the testis and epigenetically repressed in somatic tissues. Facioscapulohumeral muscular dystrophy (FSHD) is caused by mutations that decrease the epigenetic repression of DUX4 in somatic tissues and result in mis-expression of this transcr...

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Autors principals: Young, Janet M., Whiddon, Jennifer L., Yao, Zizhen, Kasinathan, Bhavatharini, Snider, Lauren, Geng, Linda N., Balog, Judit, Tawil, Rabi, van der Maarel, Silvère M., Tapscott, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836709/
https://ncbi.nlm.nih.gov/pubmed/24278031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003947
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