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Mutant IDH1 Promotes Glioma Formation In Vivo
Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). A causal role for IDH1(R132H) in gliomagenesis has been proposed, but functional validation in vivo has not been demonstrated. In this study, we assessed the role of IDH1(R132...
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| Izdano u: | Cell Rep |
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| Glavni autori: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6032974/ https://ncbi.nlm.nih.gov/pubmed/29719265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.133 |
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