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IDH1 and IDH2 Mutations in Gliomas
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2009, occur in the vast majority of low grade gliomas and secondary high grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109985/ https://ncbi.nlm.nih.gov/pubmed/23532369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11910-013-0345-4 |
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