In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation

Mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) were recently found in ~80% of WHO grade II–III gliomas and secondary glioblastomas. These mutations reduce the enzyme’s ability to convert isocitrate to α-ketoglutarate and, instead, confer a novel gain-of-function resulting in the co...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res Front
Asıl Yazarlar: Robinson, Gemma L., Philip, Beatrice, Guthrie, Matthew R., Cox, James E., Robinson, James P., VanBrocklin, Matthew W., Holmen, Sheri L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417691/
https://ncbi.nlm.nih.gov/pubmed/28480226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17980/2016.311
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