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In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation
Mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) were recently found in ~80% of WHO grade II–III gliomas and secondary glioblastomas. These mutations reduce the enzyme’s ability to convert isocitrate to α-ketoglutarate and, instead, confer a novel gain-of-function resulting in the co...
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| Publié dans: | Cancer Res Front |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417691/ https://ncbi.nlm.nih.gov/pubmed/28480226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17980/2016.311 |
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