The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis

Presenilin-1 (PS1) gene encodes the catalytic component of γ-secretase, which proteolytically processes several type I transmembrane proteins. We here present evidence that the cytosolic peptide efnB2/CTF2 produced by the PS1/γ-secretase cleavage of efnB2 ligand promotes EphB4 receptor-dependent ang...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Mol Life Sci
Main Authors: Warren, Noel A., Voloudakis, Georgios, Yoon, Yonejung, Robakis, Nikolaos K., Georgakopoulos, Anastasios
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2018
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023733/
https://ncbi.nlm.nih.gov/pubmed/29428965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-018-2762-7
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