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The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis
Presenilin-1 (PS1) gene encodes the catalytic component of γ-secretase, which proteolytically processes several type I transmembrane proteins. We here present evidence that the cytosolic peptide efnB2/CTF2 produced by the PS1/γ-secretase cleavage of efnB2 ligand promotes EphB4 receptor-dependent ang...
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| Pubblicato in: | Cell Mol Life Sci |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer International Publishing
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6023733/ https://ncbi.nlm.nih.gov/pubmed/29428965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-018-2762-7 |
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