Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. W...

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Bibliografiska uppgifter
I publikationen:Cereb Cortex
Huvudupphovsmän: Suetterlin, Philipp, Hurley, Shaun, Mohan, Conor, Riegman, Kimberley L H, Pagani, Marco, Caruso, Angela, Ellegood, Jacob, Galbusera, Alberto, Crespo-Enriquez, Ivan, Michetti, Caterina, Yee, Yohan, Ellingford, Robert, Brock, Olivier, Delogu, Alessio, Francis-West, Philippa, Lerch, Jason P, Scattoni, Maria Luisa, Gozzi, Alessandro, Fernandes, Cathy, Basson, M Albert
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018918/
https://ncbi.nlm.nih.gov/pubmed/29668850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhy058
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