Germline Chd8 haploinsufficiency alters brain development in mouse

The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8(+/del5) mice displayed normal social interactions with no repetitive behav...

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Vydáno v:Nat Neurosci
Hlavní autoři: Gompers, Andrea L., Su-Feher, Linda, Ellegood, Jacob, Copping, Nycole A., Riyadh, M. Asrafuzzaman, Stradleigh, Tyler W., Pride, Michael C., Schaffler, Melanie D., Wade, A. Ayanna, Catta-Preta, Rinaldo, Zdilar, Iva, Louis, Shreya, Kaushik, Gaurav, Mannion, Brandon J., Plajzer-Frick, Ingrid, Afzal, Veena, Visel, Axel, Pennacchio, Len A., Dickel, Diane E., Lerch, Jason P., Crawley, Jacqueline N., Zarbalis, Konstantinos S., Silverman, Jill L., Nord, Alex S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008102/
https://ncbi.nlm.nih.gov/pubmed/28671691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4592
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