Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

BACKGROUND: Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the Na(V)1.1 sodium channel alpha subunit, is one such gene with two co-active promoters. Mu...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Haigh, Jessica L., Adhikari, Anna, Copping, Nycole A., Stradleigh, Tyler, Wade, A. Ayanna, Catta-Preta, Rinaldo, Su-Feher, Linda, Zdilar, Iva, Morse, Sarah, Fenton, Timothy A., Nguyen, Anh, Quintero, Diana, Agezew, Samrawit, Sramek, Michael, Kreun, Ellie J., Carter, Jasmine, Gompers, Andrea, Lambert, Jason T., Canales, Cesar P., Pennacchio, Len A., Visel, Axel, Dickel, Diane E., Silverman, Jill L., Nord, Alex S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080386/
https://ncbi.nlm.nih.gov/pubmed/33910599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-021-00884-0
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