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Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency

The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling factors, with causal roles in neurodevelopmenta...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Wade, A. Ayanna, Lim, Kenneth, Catta-Preta, Rinaldo, Nord, Alex S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339895/
https://ncbi.nlm.nih.gov/pubmed/30692911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00481
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