Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. W...

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Detalhes bibliográficos
Publicado no:Cereb Cortex
Main Authors: Suetterlin, Philipp, Hurley, Shaun, Mohan, Conor, Riegman, Kimberley L H, Pagani, Marco, Caruso, Angela, Ellegood, Jacob, Galbusera, Alberto, Crespo-Enriquez, Ivan, Michetti, Caterina, Yee, Yohan, Ellingford, Robert, Brock, Olivier, Delogu, Alessio, Francis-West, Philippa, Lerch, Jason P, Scattoni, Maria Luisa, Gozzi, Alessandro, Fernandes, Cathy, Basson, M Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018918/
https://ncbi.nlm.nih.gov/pubmed/29668850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhy058
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