Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. W...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cereb Cortex
Autores principales: Suetterlin, Philipp, Hurley, Shaun, Mohan, Conor, Riegman, Kimberley L H, Pagani, Marco, Caruso, Angela, Ellegood, Jacob, Galbusera, Alberto, Crespo-Enriquez, Ivan, Michetti, Caterina, Yee, Yohan, Ellingford, Robert, Brock, Olivier, Delogu, Alessio, Francis-West, Philippa, Lerch, Jason P, Scattoni, Maria Luisa, Gozzi, Alessandro, Fernandes, Cathy, Basson, M Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018918/
https://ncbi.nlm.nih.gov/pubmed/29668850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhy058
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares