Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. W...

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Publicado en:Cereb Cortex
Main Authors: Suetterlin, Philipp, Hurley, Shaun, Mohan, Conor, Riegman, Kimberley L H, Pagani, Marco, Caruso, Angela, Ellegood, Jacob, Galbusera, Alberto, Crespo-Enriquez, Ivan, Michetti, Caterina, Yee, Yohan, Ellingford, Robert, Brock, Olivier, Delogu, Alessio, Francis-West, Philippa, Lerch, Jason P, Scattoni, Maria Luisa, Gozzi, Alessandro, Fernandes, Cathy, Basson, M Albert
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018918/
https://ncbi.nlm.nih.gov/pubmed/29668850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhy058
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