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Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development
BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploin...
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| 發表在: | Mol Autism |
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| Main Authors: | , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7905672/ https://ncbi.nlm.nih.gov/pubmed/33627187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00409-3 |
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