Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploin...

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發表在:Mol Autism
Main Authors: Hurley, Shaun, Mohan, Conor, Suetterlin, Philipp, Ellingford, Robert, Riegman, Kimberley L. H., Ellegood, Jacob, Caruso, Angela, Michetti, Caterina, Brock, Olivier, Evans, Romy, Rudari, Fabrizio, Delogu, Alessio, Scattoni, Maria Luisa, Lerch, Jason P., Fernandes, Cathy, Basson, M. Albert
格式: Artigo
語言:Inglês
出版: BioMed Central 2021
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905672/
https://ncbi.nlm.nih.gov/pubmed/33627187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00409-3
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