Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploin...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Mol Autism
Main Authors: Hurley, Shaun, Mohan, Conor, Suetterlin, Philipp, Ellingford, Robert, Riegman, Kimberley L. H., Ellegood, Jacob, Caruso, Angela, Michetti, Caterina, Brock, Olivier, Evans, Romy, Rudari, Fabrizio, Delogu, Alessio, Scattoni, Maria Luisa, Lerch, Jason P., Fernandes, Cathy, Basson, M. Albert
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905672/
https://ncbi.nlm.nih.gov/pubmed/33627187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00409-3
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares