Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. W...

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Détails bibliographiques
Publié dans:Cereb Cortex
Auteurs principaux: Suetterlin, Philipp, Hurley, Shaun, Mohan, Conor, Riegman, Kimberley L H, Pagani, Marco, Caruso, Angela, Ellegood, Jacob, Galbusera, Alberto, Crespo-Enriquez, Ivan, Michetti, Caterina, Yee, Yohan, Ellingford, Robert, Brock, Olivier, Delogu, Alessio, Francis-West, Philippa, Lerch, Jason P, Scattoni, Maria Luisa, Gozzi, Alessandro, Fernandes, Cathy, Basson, M Albert
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018918/
https://ncbi.nlm.nih.gov/pubmed/29668850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhy058
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