T7 RNA Polymerase Discriminates Correct and Incorrect Nucleoside Triphosphates by Free Energy

RNA polymerase (RNAP) is the primary machine responsible for transcription. Its ability to distinguish between correct (cognate) and incorrect (noncognate) nucleoside triphosphates (NTPs) is important for fidelity control in transcription. In this work, we investigated the substrate selection mechan...

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Bibliographic Details
Published in:Biophys J
Main Authors: Wu, Shaogui, Wang, Jiayang, Pu, Xuemei, Li, Laicai, Li, Quan
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2018
Subjects:
Nucleic Acids and Genome Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937113/
https://ncbi.nlm.nih.gov/pubmed/29694856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.02.033
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