T7 RNA Polymerase Discriminates Correct and Incorrect Nucleoside Triphosphates by Free Energy

RNA polymerase (RNAP) is the primary machine responsible for transcription. Its ability to distinguish between correct (cognate) and incorrect (noncognate) nucleoside triphosphates (NTPs) is important for fidelity control in transcription. In this work, we investigated the substrate selection mechan...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Wu, Shaogui, Wang, Jiayang, Pu, Xuemei, Li, Laicai, Li, Quan
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Nucleic Acids and Genome Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937113/
https://ncbi.nlm.nih.gov/pubmed/29694856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.02.033
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