T7 RNA Polymerase Discriminates Correct and Incorrect Nucleoside Triphosphates by Free Energy

RNA polymerase (RNAP) is the primary machine responsible for transcription. Its ability to distinguish between correct (cognate) and incorrect (noncognate) nucleoside triphosphates (NTPs) is important for fidelity control in transcription. In this work, we investigated the substrate selection mechan...

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Vydáno v:Biophys J
Hlavní autoři: Wu, Shaogui, Wang, Jiayang, Pu, Xuemei, Li, Laicai, Li, Quan
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2018
Témata:
Nucleic Acids and Genome Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937113/
https://ncbi.nlm.nih.gov/pubmed/29694856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.02.033
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