Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion

The mouse is a critical model in diabetes research, but most research in mice has been limited to a small number of mouse strains and limited genetic variation. Using the eight founder strains and both sexes of the Collaborative Cross (C57BL/6J (B6), A/J, 129S1/SvImJ (129), NOD/ShiLtJ (NOD), NZO/HIL...

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Udgivet i:J Biol Chem
Main Authors: Mitok, Kelly A., Freiberger, Elyse C., Schueler, Kathryn L., Rabaglia, Mary E., Stapleton, Donald S., Kwiecien, Nicholas W., Malec, Paige A., Hebert, Alexander S., Broman, Aimee T., Kennedy, Robert T., Keller, Mark P., Coon, Joshua J., Attie, Alan D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Genomics and Proteomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912463/
https://ncbi.nlm.nih.gov/pubmed/29496998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001102
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