The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets

Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated genes within these loci is regulated by a common locus in pancreatic islets. Using an obese F2 mous...

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Vydáno v:PLoS Genet
Hlavní autoři: Keller, Mark P., Paul, Pradyut K., Rabaglia, Mary E., Stapleton, Donnie S., Schueler, Kathryn L., Broman, Aimee Teo, Ye, Shuyun Isabella, Leng, Ning, Brandon, Christopher J., Neto, Elias Chaibub, Plaisier, Christopher L., Simonett, Shane P., Kebede, Melkam A., Sheynkman, Gloria M., Klein, Mark A., Baliga, Nitin S., Smith, Lloyd M., Broman, Karl W., Yandell, Brian S., Kendziorski, Christina, Attie, Alan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147809/
https://ncbi.nlm.nih.gov/pubmed/27935966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006466
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