The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets

Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated genes within these loci is regulated by a common locus in pancreatic islets. Using an obese F2 mous...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Keller, Mark P., Paul, Pradyut K., Rabaglia, Mary E., Stapleton, Donnie S., Schueler, Kathryn L., Broman, Aimee Teo, Ye, Shuyun Isabella, Leng, Ning, Brandon, Christopher J., Neto, Elias Chaibub, Plaisier, Christopher L., Simonett, Shane P., Kebede, Melkam A., Sheynkman, Gloria M., Klein, Mark A., Baliga, Nitin S., Smith, Lloyd M., Broman, Karl W., Yandell, Brian S., Kendziorski, Christina, Attie, Alan D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147809/
https://ncbi.nlm.nih.gov/pubmed/27935966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006466
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