The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets

Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated genes within these loci is regulated by a common locus in pancreatic islets. Using an obese F2 mous...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Keller, Mark P., Paul, Pradyut K., Rabaglia, Mary E., Stapleton, Donnie S., Schueler, Kathryn L., Broman, Aimee Teo, Ye, Shuyun Isabella, Leng, Ning, Brandon, Christopher J., Neto, Elias Chaibub, Plaisier, Christopher L., Simonett, Shane P., Kebede, Melkam A., Sheynkman, Gloria M., Klein, Mark A., Baliga, Nitin S., Smith, Lloyd M., Broman, Karl W., Yandell, Brian S., Kendziorski, Christina, Attie, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147809/
https://ncbi.nlm.nih.gov/pubmed/27935966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006466
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