The impact of aging on primate hematopoiesis as interrogated by clonal tracking

Age-associated changes in hematopoietic stem and progenitor cells (HSPCs) have been carefully documented in mouse models but poorly characterized in primates and humans. To investigate clinically relevant aspects of hematopoietic aging, we compared the clonal output of thousands of genetically barco...

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Bibliographic Details
Published in:Blood
Main Authors: Yu, Kyung-Rok, Espinoza, Diego A., Wu, Chuanfeng, Truitt, Lauren, Shin, Tae-Hoon, Chen, Shirley, Fan, Xing, Yabe, Idalia M., Panch, Sandhya, Hong, So Gun, Koelle, Samson, Lu, Rong, Bonifacino, Aylin, Krouse, Allen, Metzger, Mark, Donahue, Robert E., Dunbar, Cynthia E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855019/
https://ncbi.nlm.nih.gov/pubmed/29295845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-802033
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