Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque

Lentiviral vectors (LVs) are used for delivery of genes into hematopoietic stem and progenitor cells (HSPCs) in clinical trials worldwide. LVs, in contrast to retroviral vectors, are not associated with insertion site-associated malignant clonal expansions and, thus, are considered safer. Here, howe...

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Publicat a:Mol Ther
Autors principals: Espinoza, Diego A., Fan, Xing, Yang, Di, Cordes, Stefan F., Truitt, Lauren L., Calvo, Katherine R., Yabe, Idalia M., Demirci, Selami, Hope, Kristin J., Hong, So Gun, Krouse, Allen, Metzger, Mark, Bonifacino, Aylin, Lu, Rong, Uchida, Naoya, Tisdale, John F., Wu, Xiaolin, DeRavin, Suk See, Malech, Harry L., Donahue, Robert E., Wu, Chuanfeng, Dunbar, Cynthia E.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554657/
https://ncbi.nlm.nih.gov/pubmed/31023523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.04.003
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