Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque

Lentiviral vectors (LVs) are used for delivery of genes into hematopoietic stem and progenitor cells (HSPCs) in clinical trials worldwide. LVs, in contrast to retroviral vectors, are not associated with insertion site-associated malignant clonal expansions and, thus, are considered safer. Here, howe...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Espinoza, Diego A., Fan, Xing, Yang, Di, Cordes, Stefan F., Truitt, Lauren L., Calvo, Katherine R., Yabe, Idalia M., Demirci, Selami, Hope, Kristin J., Hong, So Gun, Krouse, Allen, Metzger, Mark, Bonifacino, Aylin, Lu, Rong, Uchida, Naoya, Tisdale, John F., Wu, Xiaolin, DeRavin, Suk See, Malech, Harry L., Donahue, Robert E., Wu, Chuanfeng, Dunbar, Cynthia E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554657/
https://ncbi.nlm.nih.gov/pubmed/31023523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.04.003
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