Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque

Lentiviral vectors (LVs) are used for delivery of genes into hematopoietic stem and progenitor cells (HSPCs) in clinical trials worldwide. LVs, in contrast to retroviral vectors, are not associated with insertion site-associated malignant clonal expansions and, thus, are considered safer. Here, howe...

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Bibliografski detalji
Izdano u:Mol Ther
Glavni autori: Espinoza, Diego A., Fan, Xing, Yang, Di, Cordes, Stefan F., Truitt, Lauren L., Calvo, Katherine R., Yabe, Idalia M., Demirci, Selami, Hope, Kristin J., Hong, So Gun, Krouse, Allen, Metzger, Mark, Bonifacino, Aylin, Lu, Rong, Uchida, Naoya, Tisdale, John F., Wu, Xiaolin, DeRavin, Suk See, Malech, Harry L., Donahue, Robert E., Wu, Chuanfeng, Dunbar, Cynthia E.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2019
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554657/
https://ncbi.nlm.nih.gov/pubmed/31023523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.04.003
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