Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque

Lentiviral vectors (LVs) are used for delivery of genes into hematopoietic stem and progenitor cells (HSPCs) in clinical trials worldwide. LVs, in contrast to retroviral vectors, are not associated with insertion site-associated malignant clonal expansions and, thus, are considered safer. Here, howe...

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Опубликовано в: :Mol Ther
Главные авторы: Espinoza, Diego A., Fan, Xing, Yang, Di, Cordes, Stefan F., Truitt, Lauren L., Calvo, Katherine R., Yabe, Idalia M., Demirci, Selami, Hope, Kristin J., Hong, So Gun, Krouse, Allen, Metzger, Mark, Bonifacino, Aylin, Lu, Rong, Uchida, Naoya, Tisdale, John F., Wu, Xiaolin, DeRavin, Suk See, Malech, Harry L., Donahue, Robert E., Wu, Chuanfeng, Dunbar, Cynthia E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2019
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554657/
https://ncbi.nlm.nih.gov/pubmed/31023523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.04.003
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