Nicotinamide improves aspects of healthspan but not lifespan in mice

The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan measures in mice without extending lifespan. Untargeted metabolite profiling of the liver and metabolic flux analysis of l...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Metab
Egile Nagusiak: Mitchell, Sarah J., Bernier, Michel, Aon, Miguel A., Cortassa, Sonia, Kim, Eun Young, Fang, Evandro F., Palacios, Hector H., Ali, Ahmed, Navas-Enamorado, Ignacio, Di Francesco, Andrea, Kaiser, Tamzin A., Waltz, Tyler B., Zhang, Ning, Ellis, James L., Elliott, Peter J., Frederick, David W., Bohr, Vilhelm A., Schmidt, Mark S., Brenner, Charles, Sinclair, David A., Sauve, Anthony A., Baur, Joseph A., de Cabo, Rafael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854409/
https://ncbi.nlm.nih.gov/pubmed/29514072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.02.001
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